Grisefulvin

Section 1: Chemical Product and Company Identification

Product Name: Grisefulvin

CAS#: 126-07-8

EINECS#: 204-767-4

M.F: C17H17ClO6

M.W: 352.77

Supplier: KINFON PHARMACHEM CO.,LTD

F4, No.5 Torch Ave, JLP Dist, Chongqing 400080, China

website: www.echemix.com     email: sales@echemix.com

Section 2: Composition and Information on Ingredients

Toxicological Data on Ingredients: Griseofulvin: ORAL (LD50): Acute: >50000 mg/kg [Mouse]. >10000 mg/kg [Rat].

Section 3: Hazards Identification

Potential Acute Health Effects: Slightly hazardous in case of skin contact (irritant), of eye contact (irritant), of ingestion, of inhalation.

Potential Chronic Health Effects:

CARCINOGENIC EFFECTS: Classified 2B (Possible for human.) by IARC. MUTAGENIC EFFECTS: Mutagenic for bacteria

and/or yeast. TERATOGENIC EFFECTS: Not available. DEVELOPMENTAL TOXICITY: Not available. The substance may be toxic to blood, liver, Nerves. Repeated or prolonged exposure to the substance can produce target organs damage

Section 4: First Aid Measures

Eye Contact:

Check for and remove any contact lenses. In case of contact, immediately flush eyes with plenty of water for at least 15 minutes. Get medical attention if irritation occurs.

Skin Contact: Wash with soap and water. Cover the irritated skin with an emollient. Get medical attention if irritation develops.

Serious Skin Contact: Not available.

Inhalation:

If inhaled, remove to fresh air. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical attention.

Serious Inhalation: Not available.

Ingestion:

Do NOT induce vomiting unless directed to do so by medical personnel. Never give anything by mouth to an unconscious

person. Loosen tight clothing such as a collar, tie, belt or waistband. Get medical attention if symptoms appear.

Serious Ingestion: Not available.

5. Fire Fighting Measures

Flammability of the Product: May be combustible at high temperature.

Auto-Ignition Temperature: Not available.

Flash Points: Not available.

Flammable Limits: Not available.

Products of Combustion: These products are carbon oxides (CO, CO2), halogenated compounds.

Fire Hazards in Presence of Various Substances:

Slightly flammable to flammable in presence of heat. Non-flammable in presence of shocks.

Explosion Hazards in Presence of Various Substances:

Slightly explosive in presence of open flames and sparks. Non-explosive in presence of shocks.

Fire Fighting Media and Instructions:

SMALL FIRE: Use DRY chemical powder. LARGE FIRE: Use water spray, fog or foam. Do not use water jet.

Special Remarks on Fire Hazards:

When heated to decomposition it emits toxic fumes of Hydrogen chloride gas, Carbon monoxide, and Carbon dioxide. As with most organic solids, fire is possible at elevated temperatures

Special Remarks on Explosion Hazards:

Fine dust dispersed in air in sufficient concentrations, and in the presences of an ignition source is a potential dust explosion hazard.

6. Accidental Release Measures

Small Spill:

Use appropriate tools to put the spilled solid in a convenient waste disposal container. Finish cleaning by spreading water on the contaminated surface and dispose of according to local and regional authority requirements.

Large Spill:

Use a shovel to put the material into a convenient waste disposal container. Finish cleaning by spreading water on the contaminated surface and allow to evacuate through the sanitary system.

7. Handling and Storage

Precautions:

Keep away from heat. Keep away from sources of ignition. Do not ingest. Do not breathe dust. Wear suitable protective clothing. If ingested, seek medical advice immediately and show the container or the label. Keep away from incompatibles such as oxidizing agents.

Storage: Keep container tightly closed. Keep container in a cool, well-ventilated area. Refrigerate

8. Exposure Controls/Personal Protection

Engineering Controls:

Use process enclosures, local exhaust ventilation, or other engineering controls to keep airborne levels below recommended exposure limits. If user operations generate dust, fume or mist, use ventilation to keep exposure to airborne contaminants below the exposure limit.

Personal Protection: Safety glasses. Lab coat. Dust respirator. Be sure to use an approved/certified respirator or equivalent.

Gloves.

Personal Protection in Case of a Large Spill:

Splash goggles. Full suit. Dust respirator. Boots. Gloves. A self contained breathing apparatus should be used to avoid

inhalation of the product. Suggested protective clothing might not be sufficient; consult a specialist BEFORE handling this product.

Exposure Limits: Not available.

9. Physical and Chemical Properties

Physical state and appearance: Solid. (Solid crystalline powder.)

Odor: Odorless.

Taste: Not available.

Molecular Weight: 352.77 g/mole

Color: White to Off-white.

pH (1% soln/water): Not applicable.

Boiling Point: Not available.

Melting Point: 218°C (424.4°F)

Critical Temperature: Not available.

Specific Gravity: Not available.

Vapor Pressure: Not applicable.

Vapor Density: Not available.

Volatility: Not available.

Odor Threshold: Not available.

Water/Oil Dist. Coeff.: The product is more soluble in oil; log(oil/water) = 2.2

Ionicity (in Water): Not available.

Dispersion Properties: See solubility in water, methanol, acetone.

Solubility:

Partially soluble in methanol, acetone. Insoluble in cold water, hot water. El Cloruro del hidrógeno, el

10. Stability and Reactivity Data

Stability: The product is stable.

Instability Temperature: Not available.

Conditions of Instability: Excess heat, dust generation, incompatible materials

Incompatibility with various substances: Reactive with oxidizing agents.

Corrosivity: Non-corrosive in presence of glass.

Special Remarks on Reactivity: Not available.

Special Remarks on Corrosivity: Not available.

Polymerization: Will not occur.

11. Toxicological   Information

Routes of Entry: Inhalation. Ingestion.

Toxicity to Animals: Acute oral toxicity (LD50): >10000 mg/kg [Rat].

Chronic Effects on Humans:

CARCINOGENIC EFFECTS: Classified 2B (Possible for human.) by IARC. MUTAGENIC EFFECTS: Mutagenic for bacteria

and/or yeast. May cause damage to the following organs: blood, liver, Nerves.

Other Toxic Effects on Humans: Slightly hazardous in case of skin contact (irritant), of ingestion, of inhalation.

Special Remarks on Toxicity to Animals: Not available.

Special Remarks on Chronic Effects on Humans:

May cause adverse reproductive effects and birth defects (teratogenic). May cause cancer. May affect genetic material

(mutagenic)

Special Remarks on other Toxic Effects on Humans:

Potential Health Effects: Skin: May cause skin irritation. May cause allergic skin reaction/rashes/Urticaria. Eyes: May cause

eye irritation. Inhalation: May cause irritation of the mucous membranes and upper respiratory tract. Ingestion: May cause

gastrointestinal tract irritation with nausea, vomiting, diarrhea, gastrointestinal bleeding, epigastric distress and oral thrush.

May also affect metabolism (anorexia), liver (hepatotoxicity), urinary system, nervous system (headache, peripheral neuritis,

lethargy, paresthesias of the hands and feet, vertigo, fatigue, mental confusion syncope),heart (cardiomyopathy including

infarction), blood (leukopenia, neutopenia, monocytosis, and punctate basophilia. May also cause blurred vision, menstrual

irregularities, transient macular edema, and may induce Lupus Erythmatosus. Causes photosensitivity. Exposure to light

can result in allergic reactions resulting in dermatologic lesionis, which can vary from sunburnlike responses to edematous,

vesiculated lesions or bullae. Shows cross-allergenicity with Penicillin.

12. Ecological Information

Ecotoxicity: Not available.

BOD5 and COD: Not available.

Products of Biodegradation:

Possibly hazardous short term degradation products are not likely. However, long term degradation products may arise.

Toxicity of the Products of Biodegradation: The products of degradation are more toxic than the product itself.

Special Remarks on the Products of Biodegradation: Not available.

13. Disposal Considerations

Waste Disposal:

Waste must be disposed of in accordance with federal, state and local environmental control regulations.

14. Transport Information

DOT Classification: Not a DOT controlled material (United States).

Identification: Not applicable.

Special Provisions for Transport: Not applicable

15. Other Regulatory Information and Pictograms

Federal and State Regulations:

California prop. 65: This product contains the following ingredients for which the State of California has found to cause cancer,

birth defects or other reproductive harm, which would require a warning under the statute: Griseofulvin California prop. 65:

This product contains the following ingredients for which the State of California has found to cause cancer which would require

a warning under the statute: Griseofulvin Minnesota: Griseofulvin Massachusetts RTK: Griseofulvin Massachusetts spill list:

Griseofulvin California Director's List of Hazardous Substances: Griseofulvin

Other Regulations:

OSHA: Hazardous by definition of Hazard Communication Standard (29 CFR 1910.1200). EINECS: This product is on the

European Inventory of Existing Commercial Chemical Substances.

Other Classifications:

WHMIS (Canada): Not controlled under WHMIS (Canada).

DSCL (EEC):

R33- Danger of cumulative effects. R40- Possible risks of irreversible effects. R43- May cause sensitization by skin contact.

R60- May impair fertility. R61- May cause harm to the unborn child. S22- Do not breathe dust. S24/25- Avoid contact with skin

and eyes. S36/37/39- Wear suitable protective clothing, gloves and eye/face protection. S45- In case of accident or if you feel

unwell, seek medical advice immediately (show the label where possible). S53- Avoid exposure - obtain special instructions

before use.

HMIS (U.S.A.):

Health Hazard: 1

Fire Hazard: 1

Reactivity: 0

Personal Protection: E

National Fire Protection Association (U.S.A.):

Health: 1

Flammability: 1

Reactivity: 0

Specific hazard:

Protective Equipment:

Gloves. Lab coat. Dust respirator. Be sure to use an approved/certified respirator or equivalent. Safety glasses.

Section 16: Other Information

References: Not available.

Other Special Considerations: Not available.

All information and instructions provided in this Material Safety Data Sheet (MSDS) are based on the current state of scientific and technical knowledge. And above information is only for reference.