Latamoxef Sodium

2013-12-18 14:15
2

Material Safety Data Sheet

Section 1: Chemical Product and Company Identification

Product Name: Latamoxef Sodium

CAS#: 64953-12-4

Synonym: Moxalactam sodium salt; Disodium 7-[[carboxylato(4-hydroxyphenyl)acetyl]amino]-7-methoxy-3-[[(1-methyl-1H-tetrazol-5-yl)thio]methyl]-8-oxo-5-oxa-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate

Supplier: KINFON PHARMACHEM CO.,LTD

F4, No.5 Torch Ave, JLP Dist, Chongqing 400080, China

website: www.echemix.com     email: sales@echemix.com




Section 2: Composition and Information on Ingredients

Name                 CAS #             

Latamoxef Sodium   64953-12-4                       

Section 3: Hazards Identification

Classification according to Regulation (EC) No 1272/2008 [EU-GHS/CLP]

Respiratory sensitization (Category 1)

Skin sensitization (Category 1)

Classification according to EU Directives 67/548/EEC or 1999/45/EC

May cause sensitization by inhalation and skin contact.

Label elements

Labelling according Regulation (EC) No 1272/2008 [CLP]

Signal word      Danger

Hazard statement(s)

H317           May cause an allergic skin reaction.

H334           May cause allergy or asthma symptoms or breathing difficulties if inhaled.  


Precautionary statement(s)

P261           Avoid breathing dust/ fume/ gas/ mist/ vapours/ spray.

P280           Wear protective gloves.

P342 + P311    If experiencing respiratory symptoms: Call a POISON CENTER or doctor/

physician.

Supplemental Hazard Statements          none

According to European Directive 67/548/EEC as amended.

Hazard symbol(s)   


R-phrase(s)

R42/43                    May cause sensitization by inhalation and skin contact.

S-phrase(s)

S22                       Do not breathe dust.

S36/37                    Wear suitable protective clothing and gloves.

S45                       In case of accident or if you feel unwell, seek medical advice immediately

(show the label where possible).

Section 4: First Aid Measures

General advice

Consult a physician. Show this safety data sheet to the doctor in attendance.

If inhaled

If breathed in, move person into fresh air. If not breathing, give artificial respiration. Consult a physician.

In case of skin contact

Wash off with soap and plenty of water. Consult a physician.

In case of eye contact

Flush eyes with water as a precaution.

If swallowed

Never give anything by mouth to an unconscious person. Rinse mouth with water. Consult a physician.

Most important symptoms and effects, both acute and delayed

Because of the similarity in structure of the penicillins and cephalosporins, those who are allergic to one

class of agents may manifest cross-allergenicity when a member of the other class is encountered., Nausea,

Vomiting, May occur in combination with exposure to alcohol, Significant and sometimes fatal bleeding,

interference with hemostasis via hypoprothrombinemia with or without bleeding, platelet dysfunction,

immune- mediated thrombocytopenia, To the best of our knowledge, the chemical, physical, and toxicological

properties have not been thoroughly investigated.

Indication of any immediate medical attention and special treatment needed

no data available


Section 5: Fire and Explosion Data

Extinguishing media

Suitable extinguishing media

Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide.

Special hazards arising from the substance or mixture

Carbon oxides, nitrogen oxides (NOx), Sulphur oxides, Sodium oxides

Advice for firefighters

Wear self contained breathing apparatus for fire fighting if necessary.

Further information

no data available


Section 6: Accidental Release Measures

Personal precautions, protective equipment and emergency procedures

Use personal protective equipment. Avoid dust formation. Avoid breathing vapors, mist or gas. Ensure

adequate ventilation. Evacuate personnel to safe areas. Avoid breathing dust.

Environmental precautions

Do not let product enter drains.

Methods and materials for containment and cleaning up

Pick up and arrange disposal without creating dust. Sweep up and shovel. Keep in suitable, closed containers for disposal.


Section 7: Handling and Storage

Precautions for safe handling

Avoid contact with skin and eyes. Avoid formation of dust and aerosols.

Provide appropriate exhaust ventilation at places where dust is formed.Normal measures for preventive fire

protection.

Conditions for safe storage, including any incompatibilities

Store in cool place. Keep container tightly closed in a dry and well-ventilated place.

Recommended storage temperature: 2 - 8 °C

Specific end uses          no data available


Section 8: Exposure Controls/Personal Protection

Engineering Controls:

Control parameters

Components with workplace control parameters

Exposure controls

Appropriate engineering controls

Handle in accordance with good industrial hygiene and safety practice. Wash hands before breaks and at

the end of workday.

Personal protective equipment

Eye/face protection

Face shield and safety glasses Use equipment for eye protection tested and approved under

appropriate government standards such as NIOSH (US) or EN 166(EU).

Skin protection

Handle with gloves. Gloves must be inspected prior to use. Use proper glove removal technique

(without touching glove's outer surface) to avoid skin contact with this product. Dispose of

contaminated gloves after use in accordance with applicable laws and good laboratory practices.

Wash and dry hands.

The selected protective gloves have to satisfy the specifications of EU Directive 89/686/EEC and the

standard EN 374 derived from it.

Body Protection

Complete suit protecting against chemicals, The type of protective equipment must be selected

according to the concentration and amount of the dangerous substance at the specific workplace.

Respiratory protection

For nuisance exposures use type P95 (US) or type P1 (EU EN 143) particle respirator.For higher

level protection use type OV/AG/P99 (US) or type ABEK-P2 (EU EN 143) respirator cartridges. Use

respirators and components tested and approved under appropriate government standards such as

NIOSH (US) or CEN (EU).


Section 9: Physical and Chemical Properties

a) Appearance Form: powder

Colour: light yellow

b) Odour                no data available

c) Odour Threshold       no data available

d) pH no data available

e) Melting point/freezing point              no data available

f) Initial boiling point and boiling range      no data available

g) Flash point    no data available

h) Evaporation rate    no data available

i) Flammability (solid, gas) no data available

j) Upper/lower flammability or explosive limits   no data available

k) Vapour pressure no data available

l) Vapour density    no data available

m) Relative density no data available

n) Water solubility ca.50 g/l

o) Partition coefficient: noctanol/water   no data available

p) Autoignition temperature   no data available

q) Decomposition temperature   no data available

r) Viscosity     no data available

s) Explosive properties    no data available

t) Oxidizing properties     no data available

Other safety information   no data available


Section 10: Stability and Reactivity Data

Reactivity     no data available

Chemical stability   no data available

Possibility of hazardous reactions      no data available

Conditions to avoid           Exposure to moisture may affect product quality.

Incompatible materials        Strong oxidizing agents

Hazardous decomposition products   Other decomposition products - no data available


Section 11: Toxicological Information

Acute toxicity

LD50 Oral - rat - > 10.000 mg/kg

Remarks: Diarrhoea

Skin corrosion/irritation   no data available

Serious eye damage/eye irritation   no data available

Respiratory or skin sensitization

May cause sensitization by skin contact.

May cause sensitization by inhalation.

Germ cell mutagenicity    no data available

Carcinogenicity

IARC: No component of this product present at levels greater than or equal to 0.1% is identified as

probable, possible or confirmed human carcinogen by IARC.

Reproductive toxicity   no data available

Specific target organ toxicity - single exposure       no data available

Specific target organ toxicity - repeated exposure      no data available

Aspiration hazard         no data available

Potential health effects

Inhalation May be harmful if inhaled. May cause respiratory tract irritation.

Ingestion May be harmful if swallowed.

Skin May be harmful if absorbed through skin. May cause skin irritation.

Eyes May cause eye irritation.

Signs and Symptoms of Exposure

Because of the similarity in structure of the penicillins and cephalosporins, those who are allergic to one

class of agents may manifest cross-allergenicity when a member of the other class is encountered., Nausea,

Vomiting, May occur in combination with exposure to alcohol, Significant and sometimes fatal bleeding,

interference with hemostasis via hypoprothrombinemia with or without bleeding, platelet dysfunction,

immune- mediated thrombocytopenia, To the best of our knowledge, the chemical, physical, and toxicological

properties have not been thoroughly investigated.

Additional Information    RTECS: Not available


Section 12: Ecological Information

Toxicity            no data available

Persistence and degradability         no data available

Bioaccumulative potential             no data available

Mobility in soil                        no data available

Results of PBT and vPvB assessment   no data available

Other adverse effects               no data available


Section 13: Disposal Considerations

Waste treatment methods

Product

Offer surplus and non-recyclable solutions to a licensed disposal company. Contact a licensed professional

waste disposal service to dispose of this material. Dissolve or mix the material with a combustible solvent

and burn in a chemical incinerator equipped with an afterburner and scrubber.

Contaminated packaging

Dispose of as unused product.


Section 14: Transport Information

UN number

ADR/RID: - IMDG: - IATA: -

UN proper shipping name

ADR/RID: Not dangerous goods

IMDG: Not dangerous goods

IATA: Not dangerous goods

Transport hazard class(es)

ADR/RID: - IMDG: - IATA: -

Packaging group

ADR/RID: - IMDG: - IATA: -

Environmental hazards

ADR/RID: no IMDG Marine pollutant: no IATA: no

Special precautions for user

no data available


Section 15: Other Regulatory Information

This safety datasheet complies with the requirements of Regulation (EC) No. 1907/2006.


Section 16: Other Information

References: Not available.

Other Special Considerations: Not available.

All information and instructions provided in this Material Safety Data Sheet (MSDS) are based on the current state of scientific and technical knowledge. And above information is only for reference.