Isoflurane

Section 1: Chemical Product and Company Identification

Product Name:

Product Name: Isoflurane

Synonyms ：1-Chloro-2,2,2-trifluoroethyl difluoromethyl ether

CAS Number: 26675-46-7

EINECS ：247-897-7

Supplier: KINFON PHARMACHEM CO.,LTD

F4, No.5 Torch Ave, JLP Dist, Chongqing 400080, China

website: www.echemix.com     email: sales@echemix.com

Section 2: Composition and Information on Ingredients

Chemical characterization:

Description: (CAS#)

1-Chloro-2,2,2-trifluoroethyl difluoromethyl ether

(CAS# 26675-46-7): 100%

Identification number(s):

EINECS Number: 247-897-7

Section 3: Hazards Identification

Xn Harmful

Information pertaining to particular dangers for man and environment

R 36/37/38 Irritating to eyes, respiratory system and skin.

R 62 Possible risk of impaired fertility

R 63 Possible risk of harm to the unborn child

Classification system

HMIS ratings (scale 0-4)

(Hazardous Materials Identification System)

Section 4: First Aid Measures

After inhalation

Supply fresh air. If required, provide artificial respiration. Keep

patient warm.

Seek immediate medical advice.

After skin contact

Immediately wash with water and soap and rinse thoroughly.

Seek immediate medical advice.

After eye contact

Rinse opened eye for several minutes under running water. Then consult a

doctor.

After swallowing Seek immediate medical advice.

Section 5: Fire and Explosion Data

Suitable extinguishing agents

Carbon dioxide, extinguishing powder or water spray. Fight larger fires

with water spray or alcohol resistant foam.

Special hazards caused by the material, its products of combustion or

resulting gases:

In case of fire, the following can be released:

Carbon monoxide and carbon dioxide

Hydrogen fluoride (HF)

Hydrogen chloride (HCl)

Protective equipment:

Wear self-contained respirator.

Wear fully protective impervious suit.

Section 6: Accidental Release Measures

Person-related safety precautions:

Wear protective equipment. Keep unprotected persons away.

Ensure adequate ventilation

Measures for environmental protection:

Do not allow material to be released to the environment without proper

governmental permits.

Measures for cleaning/collecting:

Absorb with liquid-binding material (sand, diatomite, acid binders,

universal binders, sawdust).

Dispose contaminated material as waste according to item 13.

Ensure adequate ventilation.

Additional information:

See Section 7 for information on safe handling

See Section 8 for information on personal protection equipment.

See Section 13 for disposal information.

Section 7: Handling and Storage

Handling

Information for safe handling:

Keep container tightly sealed.

Store in cool, dry place in tightly closed containers.

Ensure good ventilation at the workplace.

Information about protection against explosions and fires:

Keep ignition sources away.

Storage

Requirements to be met by storerooms and receptacles:

No special requirements.

Information about storage in one common storage facility:

Store away from oxidizing agents.

Further information about storage conditions:

Keep container tightly sealed.

Store in cool, dry conditions in well sealed containers.

Section 8: Exposure Controls/Personal Protection

Additional information about design of technical systems:

Properly operating chemical fume hood designed for hazardous chemicals

and having an average face velocity of at least 100 feet per minute.

Components with limit values that require monitoring at the workplace:

Not required.

Additional information: No data

Personal protective equipment

General protective and hygienic measures

The usual precautionary measures for handling chemicals should be

followed.

Keep away from foodstuffs, beverages and feed.

Remove all soiled and contaminated clothing immediately.

Wash hands before breaks and at the end of work.

Avoid contact with the eyes and skin.

Breathing equipment:

Use suitable respirator when high concentrations are present.

Protection of hands:

Impervious gloves

Check protective gloves prior to each use for their proper condition.

Material of gloves

The selection of suitable gloves not only depends on the material, but

also on quality.   Quality will vary from manufacturer to manufacturer.

Eye protection: Safety glasses

Body protection: Protective work clothing.

Section 9: Physical and Chemical Properties

Form: Liquid

Color: Colorless

Odor: Not determined

Change in condition

Melting point/Melting range: Not determined

Boiling point/Boiling range: 48-49°C (118-120°F)

Sublimation temperature / start: Not determined

Flash point: Not determined

Ignition temperature: Not determined

Decomposition temperature: Not determined

Danger of explosion: Product does not present an explosion hazard.

Explosion limits:

Lower: Not determined

Upper: Not determined

Vapor pressure: Not determined

Density at 20°C (68°F): 1.496 g/cm³

Solubility in / Miscibility with

Water: Not miscible or difficult to mix

Section 10: Stability and Reactivity Data

Thermal decomposition / conditions to be avoided:

Decomposition will not occur if used and stored according to

specifications.

Materials to be avoided: Oxidizing agents

Dangerous reactions No dangerous reactions known

Dangerous products of decomposition:

Carbon monoxide and carbon dioxide

Hydrogen fluoride

Hydrogen chloride (HCl)

Section 11: Toxicological Information

Acute toxicity:

LD/LC50 values that are relevant for classification:

Oral LD50 5080 µL/kg (mouse)    4770 µL/kg (rat)

Inhalative LC50/3H 16800 ppm/3H (mouse)      15300 ppm/3H (rat)

Primary irritant effect:

on the skin: Irritant to skin and mucous membranes.

on the eye: Irritating effect.

Sensitization: No sensitizing effects known.

Other information (about experimental toxicology):

Reproductive effects have been observed on tests with laboratory animals.

Mutagenic effects have been observed on tests with laboratory animals.

Mutagenic effects have been observed with humans.

Subacute to chronic toxicity:

Subacute to chronic toxicity:

The Registry of Toxic Effects of Chemical Substances (RTECS) reports the

following effects in laboratory animals:

Brain and Coverings - changes in surface EEG

Brain and Coverings - other degenerative changes.

Biochemical - Enzyme inhibition, induction, or change in blood or tissue

levels - other enzymes.

Biochemical - Metabolism (Intermediary) - other.

Behavioral - muscle weakness.

Behavioral - ataxia.

Behavioral - analgesia.

Behavioral - excitement.

Behavioral - somnolence (general depressed activity).

Endocrine - changes in adrenal weight.

Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol).

Related to Chronic Data - death.

Cardiac - change in rate.

Vascular - BP lowering not characterized in autonomic section.

Vascular - other changes.

Lungs, Thorax, or Respiration - respiratory depression

Nutritional and Gross Metabolic - body temperature decrease.

Nutritional and Gross Metabolic - weight loss or decreased weight gain.

Blood - changes in leukocyte (WBC) count.

Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death,

e.g., stunted fetus).

Reproductive - Effects on Newborn - physical.

Reproductive - Specific Developmental Abnormalities - craniofacial

(including nose and tongue).

Reproductive - Specific Developmental Abnormalities - musculoskeletal

system.

Reproductive - Specific Developmental Abnormalities - urogenital system.

Additional toxicological information:

To the best of our knowledge the acute and chronic toxicity of this

substance is not fully known.

Possible risk of impaired fertility.

Possible risk of harm to the unborn child.

No classification data on carcinogenic properties of this material is

available from the EPA, IARC, NTP, OSHA or ACGIH.

Section 12: Ecological Information

General notes:

Do not allow undiluted product or large quantities of it to reach ground

water, water course or sewage system.

Do not allow material to be released to the environment without proper

governmental permits.

Section 13: Disposal Considerations
Product:

Recommendation

Consult state, local or national regulations to ensure proper disposal.

Uncleaned packagings:

Recommendation: Disposal must be made according to official regulations.

Section 14: Transport Information

Not a hazardous material for transportation.

DOT regulations:

Hazard class: None

Land transport ADR/RID   (cross-border)

ADR/RID class: None

Maritime transport IMDG:

IMDG Class: None

Air transport ICAO-TI and IATA-DGR:

ICAO/IATA Class: None

Transport/Additional information:

Not dangerous according to the above specifications

Section 15: Other Regulatory Information

Product related hazard informations:

Hazard symbols:

Xn Harmful

Risk phrases:

36/37/38 Irritating to eyes, respiratory system and skin.

62 Possible risk of impaired fertility

63 Possible risk of harm to the unborn child

Safety phrases:

26 In case of contact with eyes, rinse immediately with plenty of

water and seek medical advice.

36/37 Wear suitable protective clothing and gloves.

National regulations

This product is not listed in the U.S. Environmental Protection Agency

Toxic Substances Control Act Chemical Substance Inventory.   Use of this

product is restricted to research and development only.

Some or all of the components of this product are not listed on the

Canadian Domestic Substances List (DSL) or the Canadian Non-Domestic

Substances List (NDSL).

Information about limitation of use:

For use only by technically qualified individuals.

Section 16: Other Information

References: Not available.

Other Special Considerations: Not available.

All information and instructions provided in this Material Safety Data Sheet (MSDS) are based on the current state of scientific and technical knowledge. And above information is only for reference.