Progesterone

Section 1: Chemical Product and Company Identification

Product Name: Progesterone

CAS#: 57-83-0

EINECS#: 200-350-6

Supplier: KINFON PHARMACHEM CO.,LTD

F4, No.5 Torch Ave, JLP Dist, Chongqing 400080, China

website: www.echemix.com     email: sales@echemix.com

Section 2: Composition and Information on Ingredients

Name                CAS #                     Synonyms

Progesterone           57-83-0       

Progestin; Lutren; Lutein; Flavolutan; Corporin; Luteal hormone; 4-Pregnene-3,20-dione

Section 3: Hazards Identification

Potential Acute Health Effects:

Hazardous in case of ingestion, of inhalation. Slightly hazardous in case of skin contact (irritant), of eye contact (irritant).

Potential Chronic Health Effects:

CARCINOGENIC EFFECTS: Classified 2B (Possible for human.) by IARC. Classified 2 (Some evidence.) by NTP.

MUTAGENIC EFFECTS: Not available. TERATOGENIC EFFECTS: Classified POSSIBLE for human. DEVELOPMENTAL

TOXICITY: Classified Reproductive system/toxin/female, Reproductive system/toxin/male [POSSIBLE]. The substance is toxic

to the reproductive system. Repeated or prolonged exposure to the substance can produce target organs damage.

Section 4: First Aid Measures

Eye Contact:

p. 2

Check for and remove any contact lenses. In case of contact, immediately flush eyes with plenty of water for at least 15

minutes. Get medical attention if irritation occurs.

Skin Contact:Wash with soap and water. Cover the irritated skin with an emollient. Get medical attention if irritation develops.

Serious Skin Contact:Not available.

Inhalation:

If inhaled, remove to fresh air. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical

attention.

Serious Inhalation:Not available.

Ingestion:

Do NOT induce vomiting unless directed to do so by medical personnel. Never give anything by mouth to an unconscious

person. If large quantities of this material are swallowed, call a physician immediately. Loosen tight clothing such as a collar,

tie, belt or waistband.

Serious Ingestion:Not available.

Section 5: Fire and Explosion Data

Flammability of the Product:May be combustible at high temperature.

Auto-Ignition Temperature:Not available.

Flash Points:CLOSED CUP: Higher than 93.3°C (200°F).

Flammable Limits:Not available.

Products of Combustion:These products are carbon oxides (CO, CO2).

Fire Hazards in Presence of Various Substances:

Slightly flammable to flammable in presence of heat. Non-flammable in presence of shocks.

Explosion Hazards in Presence of Various Substances:

Risks of explosion of the product in presence of mechanical impact: Not available. Risks of explosion of the product in

presence of static discharge: Not available.

Fire Fighting Media and Instructions:

SMALL FIRE: Use DRY chemical powder. LARGE FIRE: Use water spray, fog or foam. Do not use water jet.

Special Remarks on Fire Hazards:As with most organic solids, fire is possible at elevated temperatures

Special Remarks on Explosion Hazards:

Fine dust dispersed in air in sufficient concentrations, and in the presences of an ignition source is a potential dust explosion

hazard.

Section 6: Accidental Release Measures

Small Spill:

Use appropriate tools to put the spilled solid in a convenient waste disposal container. Finish cleaning by spreading water on the contaminated surface and dispose of according to local and regional authority requirements.

Large Spill:

Use a shovel to put the material into a convenient waste disposal container. Finish cleaning by spreading water on the contaminated surface and allow to evacuate through the sanitary system.

Section 7: Handling and Storage

Precautions:

Keep away from heat. Keep away from sources of ignition. Do not breathe dust. Wear suitable protective clothing. In case of insufficient ventilation, wear suitable respiratory equipment. If you feel unwell, seek medical attention and show the label when possible. Keep away from incompatibles such as oxidizing agents.

Storage:

Keep container tightly closed. Keep container in a cool, well-ventilated area. Do not store above 25°C (77°F). Ne pas emmagasiner aux temperatures au-dessus de No almacene en temperaturas sobre de Sensitive to light. Store in light-resistant containers.

8. EXPOSURE CONTROLS/PERSONAL PROTECTION

Engineering Controls:

Use process enclosures, local exhaust ventilation, or other engineering controls to keep airborne levels below recommended exposure limits. If user operations generate dust, fume or mist, use ventilation to keep exposure to airborne contaminants below the exposure limit.

Personal Protection:Safety glasses. Lab coat. Dust respirator. Be sure to use an approved/certified respirator or equivalent.

Gloves.

Personal Protection in Case of a Large Spill:

Splash goggles. Full suit. Dust respirator. Boots. Gloves. A self contained breathing apparatus should be used to avoid inhalation of the product. Suggested protective clothing might not be sufficient; consult a specialist BEFORE handling this product.

Exposure Limits:Not available.

Section 9: Physical and Chemical Properties

Physical state and appearance:Solid. (Microcrystalline solid powder.)

Odor:Odorless.

Taste:Not available.

Molecular Weight:314.47 g/mole

Color:White.

pH (1% soln/water):Not applicable.

Boiling Point:Not available.

Melting Point:129.5°C (265.1°F)

Critical Temperature:Not available.

Specific Gravity:1.17 (Water = 1)

Vapor Pressure:Not applicable.

Vapor Density:Not available.

Volatility:Not available.

Odor Threshold:Not available.

Water/Oil Dist. Coeff.:Not available.

Ionicity (in Water):Not available.

Dispersion Properties:See solubility in water, acetone.

Solubility:

Soluble in acetone. Insoluble in cold water, hot water.

Section 10: Stability and Reactivity Data

Stability:The product is stable.

Instability Temperature:Not available.

Conditions of Instability:Light, incompatible materials.

Incompatibility with various substances:Reactive with oxidizing agents.

Corrosivity:Non-corrosive in presence of glass.

Special Remarks on Reactivity:May decompose on exposure to light.

Special Remarks on Corrosivity:Not available.

Polymerization:Will not occur.

Section 11: Toxicological Information

Routes of Entry:Not available.

Toxicity to Animals:

LD50: Not available. LC50: Not available.

Chronic Effects on Humans:

CARCINOGENIC EFFECTS: Classified 2B (Possible for human.) by IARC. Classified 2 (Some evidence.) by NTP.

TERATOGENIC EFFECTS: Classified POSSIBLE for human. DEVELOPMENTAL TOXICITY: Classified Reproductive system/toxin/female, Reproductive system/toxin/male [POSSIBLE]. Causes damage to the following organs: the reproductive system.

Other Toxic Effects on Humans:

Hazardous in case of ingestion, of inhalation. Slightly hazardous in case of skin contact (irritant).

Special Remarks on Toxicity to Animals:Not available.

Special Remarks on Chronic Effects on Humans:

May cause adverse reproductive effects and birth defects (teratogenic). May affect genetic material. May cause cancer(tumorigenic) based on animal data.

Special Remarks on other Toxic Effects on Humans:

Acute Potential Health Effects: Skin: May cause skin irritation. Eyes: Dust may cause eye irritation. Inhalation: Dust may cause respiratory tract irritation. Ingestion: May cause gastrointestinal tract irritation including diarrhea and nausea. May affect behavior, liver, and metabolism

Section 12: Ecological Information

Ecotoxicity:Not available.

BOD5 and COD:Not available.

Products of Biodegradation:

Possibly hazardous short term degradation products are not likely. However, long term degradation products may arise.

Toxicity of the Products of Biodegradation:The product itself and its products of degradation are not toxic.

Special Remarks on the Products of Biodegradation:Not available.

Section 13: Disposal Considerations
Waste Disposal:

Waste must be disposed of in accordance with federal, state and local environmental control regulations.

Section 14: Transport Information

DOT Classification:Not a DOT controlled material (United States).

Identification:Not applicable.

Special Provisions for Transport:Not applicable.

Section 15: Other Regulatory Information

Federal and State Regulations:

California prop. 65: This product contains the following ingredients for which the State of California has found to cause

cancer, birth defects or other reproductive harm, which would require a warning under the statute: Progesterone California

prop. 65: This product contains the following ingredients for which the State of California has found to cause cancer which

would require a warning under the statute: Progesterone Pennsylvania RTK: Progesterone Florida: Progesterone Minnesota:

Progesterone Massachusetts RTK: Progesterone New Jersey: Progesterone California Director's List of Hazardous

Substances: Progesterone TSCA 8(b) inventory: Progesterone

Other Regulations:EINECS: This product is on the European Inventory of Existing Commercial Chemical Substances.

Other Classifications:

WHMIS (Canada):Not controlled under WHMIS (Canada).

DSCL (EEC):

R40- Possible risks of irreversible effects. S36/37- Wear suitable protective clothing and gloves. S45- In case of accident or if

you feel unwell, seek medical advice immediately (show the label where possible).

HMIS (U.S.A.):

Health Hazard:1

Fire Hazard:1

Reactivity:0

Personal Protection:E

National Fire Protection Association (U.S.A.):

Health:1

Flammability:1

Reactivity:0

Specific hazard:

Protective Equipment:

Gloves. Lab coat. Dust respirator. Be sure to use an approved/certified respirator or equivalent. Safety glasses.

Section 16: Other Information

References: Not available.

Other Special Considerations: Not available.

All information and instructions provided in this Material Safety Data Sheet (MSDS) are based on the current state of scientific and technical knowledge. And above information is only for reference.